Policy · 2026-07-06
Federal Register: DEA Proposes Schedule I for Mitragynine Pseudoindoxyl, MGM-15, and MGM-16
Source: Federal Register
Why it matters
Three synthetic opioid compounds derived from kratom chemistry — products of research labs that migrated to gas station shelves — are now formally proposed for Schedule I, which would make their manufacture, sale, or possession federally illegal.
The big picture
Mitragynine pseudoindoxyl first appeared in commercial products in 2024. MGM-15 hit retail in September 2025. Both are now sold as flavored chewable tablets in smoke shops and online, often marketed under deceptive "botanical" branding. The DEA found 25 fatal overdose events involving mitragynine pseudoindoxyl between February 2025 and February 2026 in its toxicology program data.
Key findings
- Mitragynine pseudoindoxyl is approximately 100 times more potent than mitragynine at the mu-opioid receptor; MGM-15 is about 50 times more potent than morphine; MGM-16 is roughly 240 times more potent than morphine in animal models
- DEA toxicology data identified mitragynine pseudoindoxyl in at least 31 overdose cases from Feb 2025 to Feb 2026, of which 25 were fatal
- Products are sold under brand names including Kama, Hydroxie, Fruity Perks, and Happie Tabs at prices of $2-4 per tablet
- Of 51 online mitragynine pseudoindoxyl products analyzed, 76% were chewable tablets, 35 had appealing flavors, and 32 used bright consumer-friendly packaging
- The temporary scheduling order is expected to publish on or after August 5, 2026, lasting up to two years with a possible one-year extension
What they say
HHS Secretary Robert F. Kennedy, Jr. stated: "I commend the DEA for taking decisive action to address these addictive and harmful substances. 7-OH, MP, MGM-15, and MGM-16 are dangerous opioids that fuel addiction and put American lives at risk. HHS reviewed the science and recommended this action."
Bottom line
Three kratom-derived synthetic opioids — some up to 240 times more potent than morphine — are headed for Schedule I federal prohibition as early as August 5, 2026.