Policy · 2026-06-23
Florida Attorney General Signs New Emergency Rule Expanding 7-OH Ban to Cover Chemical Analogs
Source: WUSF Public Media
Why it matters
Florida's expanded emergency rule, signed June 23, 2026, attempts to close loopholes that allowed manufacturers to reformulate 7-OH products to evade the original ban — a cat-and-mouse pattern that regulators say is common when concentrated psychoactive compounds face partial restrictions.
The big picture
Florida was among the first states to take emergency regulatory action on 7-OH, issuing an initial rule about a year before this expansion that capped 7-OH concentrations. However, manufacturers responded by introducing chemically similar compounds — analogs such as mitragynine pseudoindoxyl and MGM-15 — that mimicked 7-OH's effects while technically remaining legal. The new rule explicitly names seven compounds and adds a ratio requirement designed to prevent super-concentrated formulations.
Key findings
- Florida medical examiners have linked at least 587 overdose deaths to 7-OH and related compounds since 2013
- The new emergency rule covers seven specific chemicals: 7-hydroxymitragynine (7-OH), mitragynine pseudoindoxyl, 7-acetoxymitragynine, 9-hydroxycorynantheidine, 10-hydroxycorynantheidine, MGM-15, and MGM-16
- Any product containing these compounds may not exceed 1 milligram per gram or milliliter; products must also contain at least 100 times more mitragynine by mass to prevent concentrated formulas
- Violators can face up to 30 years in prison under Florida's updated emergency scheduling rule
- Florida Poison Control received 95 calls about 7-OH products in just the first four months of 2026, on pace to exceed the full-year total for 2025
What they say
"Florida medical examiners have linked at least 587 overdose deaths to 7-OH and related chemical compound drugs. We are going to make sure that new chemical compounds that are being used to blend or substitute 7-OH derivatives will be included." — Florida Attorney General James Uthmeier
Bottom line
Florida's expanded emergency rule targets chemical analogs used to circumvent the original 7-OH ban, signaling that regulators are shifting from compound-specific restrictions to broader analog scheduling — a model other states may follow.