Expanded, 6th grade reading level summary:

Opioid addiction is a serious problem around the world. People who are addicted to opioids can’t stop using them, even when it causes them problems. This review explains the different medicines that can be used to treat opioid addiction in adults.

The review talks about medicines like methadone, buprenorphine, and naltrexone. These medicines can help reduce cravings for opioids and prevent overdoses. The review also discusses newer treatments that may help by reducing inflammation in the brain. The review looks at the pros and cons of the different medicines and how they work in the body.

This was a review study, not an experiment. The authors looked at many different studies on opioid
addiction treatments that were done in the real world with human patients

Key takeaways:

• Opioid addiction is a major problem around the world
• There are several medicines that can be used to treat opioid addiction
• The medicines work in different ways, such as reducing cravings or preventing overdoses
• Newer treatments that target inflammation in the brain may also be helpful
• More research is needed to find the most effective treatments for opioid addiction

For further reading:

Link: https://pubmed.ncbi.nlm.nih.gov/36295428/

Full Citation:

Leyrer-Jackson JM, Acua AM, Olive MF. Current and emerging pharmacotherapies for opioid dependence treatments in adults: a comprehensive update. Expert Opin Pharmacother. 2022 Nov;23(16):1819-1830. doi: 10.1080/14656566.2022.2140039. Epub 2022 Oct 25. PMID: 36295428.