Expanded Summary (6th grade reading level): Speciociliatine is a chemical found in a plant called kratom. Kratom has been used for a long time in parts of Southeast Asia to help with pain, opioid addiction, and to boost mood and energy. Speciociliatine is similar to another chemical in kratom called mitragynine, but it may have different effects on the body.
The researchers studied how speciociliatine is broken down and used by the body in different animals, including mice, rats, dogs, monkeys, and humans. They found that speciociliatine is broken down quickly in mice, rats, and monkeys, but more slowly in humans and dogs. They also found that speciociliatine is broken down by an enzyme called CYP3A4, which is important for knowing how other drugs might interact with speciociliatine. This information can help researchers understand how speciociliatine might affect the body and how it could be used as a medicine.
This study was done in a laboratory, not in the real world. It used samples of liver and cells from different animals and humans to see how speciociliatine is broken down. It did not involve testing speciociliatine in living animals or humans.
Key takeaways:
- Speciociliatine is broken down quickly in mice, rats, and monkeys, but more slowly in humans and dogs.
- Speciociliatine is broken down mainly by the CYP3A4 enzyme.
- This information can help researchers understand how speciociliatine might affect the body and how it could be used as a medicine.
- The study was done in a laboratory, not in the real world, and did not involve testing speciociliatine in living animals or humans
For further reading:
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC9296592
Full Citation:
Kamble SH, Berthold EC, Kanumuri SRR, King TI, Kuntz MA, Lenc F, Mottinelli M, McMahon LR, McCurdy CR, Sharma A. Metabolism of speciociliatine, an overlooked kratom alkaloid for its potential pharmacological effects. AAPS J. 2022 Jun 24;24(5):86. doi:10.1208/s12248-022-00736-8. Epub ahead of print. PMID: 35745204; PMCID: PMC9296592
